Ischemic hindlimb/Angiogenesis Human vessels can remodel as a response to different stimuli. The underlying processes are thought to be angiogenesis (proliferation of capillaries) and arteriogenesis (enlargement of preexisting arterioles). Understanding these could potentially result in better treatment options for patients suffering from clinical conditions characterized by insufficient blood supply (e.g. peripheral arterial disease). For this purpose, many researchers use the ischemic hind-limb model, an animal model in which ischemia is produced by femoral artery ligation.1 PeriScan PIM3 System offers an excellent option to follow the microcirculatory blood perfusion in this model. 1. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Limbourg A, Korff T, Napp LC, Schaper W, Drexler H, Limbourg FP Nat Protocol. 2009;4(12):1737-46

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