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Endothelial dysfunction

The endothelium is the thin layer of cells lining the interior of every vessel in the circulatory system. It plays a central role in processes such as blood pressure regulation. Endothelial dysfunction is characterized by a disturbed endothelium-dependent vasodilation and decreased bioavailability of nitric oxide. It has been observed in several diseases and has been widely studied as it is often an early disease event in these.

Assessing endothelial dysfunction

Endothelial dysfunction can be assessed in various ways using a variety of Perimed equipment and examination forms. Please read more about the various applications in the product pages below.

The PeriFlux System 5000 is not available within the EU and the EEA.

Iontophoresis Iontophoresis
Raynaud Raynaud

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Improving quality of life since 1981

Perimed AB, established in 1981, provides instruments, software and expertise to enable assessment of the microcirculation. We utilize laser Doppler, laser speckle (LASCA) and transcutaneous oxygen (tcpO2 or TCOM), to accurately monitor and quantify blood perfusion and tissue oxygenation in real-time. Our modular PeriFlux System 5000 and PeriFlux 6000, the latest generation of our PeriFlux System, are excellent choices for diagnosing Peripheral Arterial Disease (PAD) and Critical Limb Ischemia (CLI) or for assessing wound healing potential in your vascular patients. Our blood perfusion imager PeriCam PSI System allows you to investigate spatial distribution, for example during cortical spreading depression.