Peripheral Arterial Disease (PAD) is a condition caused by obstruction of the peripheral arteries leading to an increased risk for cardiovascular events and premature death.
The classical PAD symptom is intermittent claudication or walking pain, but notably two-thirds of all patients are asymptomatic.
Microcirculation is the blood flow through the smallest vessels in the circulatory system, i.e. arterioles, venules, shunts and capillaries. Microcirculation exists in all tissues and organs except for the cornea. Laser Doppler Perfusion Monitoring (LDPM), laser speckle contrast analysis (LASCA) and transcutaneous oximetry (tcpO2) are well-known techniques for studying microcirculation.
Predicting wound healing is an essential step in the management of ischemic ulcers and diabetic foot ulcers. It is estimated that early detection and appropriate treatments may prevent up to 85% of amputations.
A wounds likelihood of healing is based on 3 different parameters, the size of the wound, level of ischemia and the grade of infection, this is summarized in the WIfI classification.