{"id":1102,"date":"2024-12-20T17:16:07","date_gmt":"2024-12-20T17:16:07","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=application&#038;p=1102"},"modified":"2025-06-17T12:46:50","modified_gmt":"2025-06-17T12:46:50","slug":"peripheral-artery-disease-pad","status":"publish","type":"application","link":"https:\/\/www.perimed-instruments.com\/us\/applications\/clinical-and-clinical-research\/peripheral-artery-disease-pad\/","title":{"rendered":"Peripheral artery disease \u2014 PAD"},"content":{"rendered":"<section class=\"relative w-full mx-auto pt-24 2xl:pt-24 pb-24 2xl:pb-24 none\">\n                                                \n                                        <div class=\"sec-bg sec-bg-laptop absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-hero-white-blur-right.webp);background-size:cover;background-position:center;\"><\/div>\n                                        <div class=\"sec-bg sec-bg-mobile absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-hero-white-blur-right.webp);background-size:cover;background-position:center;\"><\/div>\n                                        <div class=\"sec-bg sec-bg-wide absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-hero-white-blur-right.webp);background-size:cover;background-position:center;\"><\/div>\n                                        \n\n        <div class=\"section__content  max-w-screen-xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-4d085cea wp-block-group-is-layout-constrained\"><div class=\"yoast-breadcrumbs\"><span><span><a href=\"https:\/\/www.perimed-instruments.com\/us\/\">Home<\/a><\/span> \/ <span><a href=\"https:\/\/www.perimed-instruments.com\/us\/applications\/\">Applications<\/a><\/span> \/ <span><a href=\"https:\/\/www.perimed-instruments.com\/us\/applications\/clinical-and-clinical-research\/\">Clinical<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">Peripheral artery disease \u2014 PAD<\/span><\/span><\/div>\n\n\n<h1 class=\"wp-block-heading pb-8 has-h-1-font-size\" id=\"h-peripheral-artery-disease-pad\">Peripheral artery disease \u2014 PAD<\/h1>\n\n\n\n<p class=\"has-text-hero-font-size\" style=\"font-style:normal;font-weight:400\">Peripheral artery disease (PAD) affects over 113 million people globally, contributing to pain, disability, and, in severe cases, amputation. Early detection and accurate monitoring are critical for managing this chronic condition. To facilitate this, we offer noninvasive diagnostic solutions for macro- and microcirculatory assessment. We design for ease of use and patient comfort, providing insights for disease assessment, progression tracking, and treatment efficacy.<\/p>\n\n\n<div class=\"gn-spacer-block pb-10\">\n    <\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#contact-form\">Contact Sales<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image alignright size-full is-style-rounded\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"550\" src=\"https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/primed-peripheral-artery-disease-2.webp\" alt=\"primed peripheral artery disease\" class=\"wp-image-2994\" srcset=\"https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/primed-peripheral-artery-disease-2.webp 800w, https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/primed-peripheral-artery-disease-2-300x206.webp 300w, https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/primed-peripheral-artery-disease-2-768x528.webp 768w, https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/primed-peripheral-artery-disease-2-769x530.webp 769w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n        <\/div>\n    <\/section>\n\n\n<section class=\"relative w-full mx-auto pt-24 2xl:pt-24 pb-12 2xl: none\" id=\"learn-more\">\n                        \n\n        <div class=\"section__content  max-w-4xl px-4 mx-auto sec_no_tabs\" >\n            \n<section class=\"relative w-full radius-8 mx-auto pt-40 2xl:pt-48 pb-40 2xl:pb-48 none\">\n                                                \n                                        <div class=\"sec-bg sec-bg-laptop absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-quote.webp);background-size:100% 100%;background-position:center;\"><\/div>\n                                        <div class=\"sec-bg sec-bg-mobile absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-quote.webp);background-size:cover;background-position:center;\"><\/div>\n                                        <div class=\"sec-bg sec-bg-wide absolute top-0 inset-0 flex justify-center overflow-hidden bg-no-repeat w-full h-full pointer-events-none z-[-1]\" style=\"background-image: url(https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/bg-quote.webp);background-size:100% 100%;background-position:center;\"><\/div>\n                                        \n\n        <div class=\"section__content  max-w-4xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<p class=\"has-text-align-center has-text-hero-font-size\">According to <sup><a href=\"#references\">[1]<\/a><\/sup>, the prevalence of PAD <br>increased by 72% between 1990 and 2019.<\/p>\n\n\n        <\/div>\n    <\/section>\n\n\n        <\/div>\n    <\/section>\n\n\n<section class=\"relative w-full mx-auto pt-12 2xl:pt-12 pb-12 2xl:pb-12 none\">\n                        \n\n        <div class=\"section__content  max-w-4xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<h3 class=\"wp-block-heading has-h-2-font-size\" id=\"h-advanced-diagnostics-for-pad-assessment\">Advanced diagnostics for PAD assessment<\/h3>\n\n\n\n<p class=\"has-p-regular-font-size\">Our devices leverage laser Doppler and advanced signal processing technologies to provide robust vascular health insights. We have designed our solutions to detect the unique challenges associated with PAD, especially in high-risk groups like people with diabetes, who are prone to complications like arterial calcification, chronic wounds, and critical limb-threatening ischemia (CLTI), and who may have falsely elevated ABI readings.&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Laser Doppler flowmetry<\/strong> provides real-time, noninvasive assessment of blood perfusion. Microcirculation assessment is a critical element of diagnosis in diabetic patients as conventional testing does not always reveal the reduced blood flow in small vessels prevalent in diabetes-related microvascular complications<sup><a href=\"#references\">[2]<\/a><\/sup>.<\/li>\n\n\n\n<li><strong>TcpO2<\/strong> offers an alternative to macrocirculation tests such as ankle and toe pressures by directly measuring skin oxygenation \u2014 a reliable indicator for people with arterial calcification. TcpO2 is especially useful in detecting areas with reduced oxygenation, a critical ischemia marker, as it indicates impaired wound healing.<\/li>\n\n\n\n<li><strong>Skin perfusion pressure (SPP) <\/strong>is an alternative to TcpO for patients with edema or wounds on the sole of the foot. It is useful for assessing wound-healing prognosis and the effectiveness of treatment or revascularization.&nbsp;<\/li>\n\n\n\n<li><strong>Laser speckle contrast imaging (LSCI<\/strong>) provides wide-area real-time visualization of blood perfusion. This non-contact, noninvasive approach is useful for monitoring the progression of PAD and identifying areas where tissue perfusion is compromised.<\/li>\n<\/ul>\n\n\n        <\/div>\n    <\/section>\n\n\n<section class=\"relative w-full mx-auto  pb-12 md:pb-12 2xl:pb-12 none\">\n                        \n\n        <div class=\"section__content  max-w-screen-xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<div class=\"wp-block-columns are-vertically-aligned-center column-reverse-mobile is-layout-flex wp-container-core-columns-is-layout-89b078ac wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading has-h-2-font-size\" id=\"h-periflux-6000-combined-for-pad\">PeriFlux 6000 Combined for PAD<\/h3>\n\n\n\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-5f1e7b9a wp-block-group-is-layout-constrained\">\n<p class=\"has-p-regular-font-size\">A powerful, all-in-one vascular care solution designed for efficient patient management and delivery of a comprehensive set of macro- and microvascular measurements. Equipped with noninvasive sensors, it captures a wide range of critical vascular data, including toe pressure, segmental limb pressures, TcpO2, and skin perfusion pressure (SPP).<\/p>\n\n\n<div class=\"gn-spacer-block pb-4\">\n    <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-9a551769 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-aaf875ba wp-block-group-is-layout-constrained\">\n<ul class=\"wp-block-list\">\n<li class=\"has-p-regular-font-size\">Supports simultaneous TcpO2 and macrocirculation pressure exams \u2014 helping to optimize time and resources.&nbsp;<\/li>\n\n\n\n<li>Comprehensive assessment capabilities \u2014 no need for multiple visits as all measurements are captured in one session.&nbsp;<\/li>\n\n\n\n<li>Heated laser Doppler probes for sensitive toe pressure measurement <sup><a href=\"#references\">[3]<\/a><\/sup>.&nbsp;<\/li>\n\n\n\n<li class=\"has-p-regular-font-size\">EMR connectivity via DICOM\/HL7 interface.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/us\/products\/periflux-vascular-systems\/periflux-6000\/combined\">Learn more about PeriFlux 6000 Combined<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"586\" src=\"https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/periflux_6000_segmental_pressure_start-1.webp\" alt=\"periflux 6000 segmental pressure start (1)\" class=\"wp-image-1104\" srcset=\"https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/periflux_6000_segmental_pressure_start-1.webp 800w, https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/periflux_6000_segmental_pressure_start-1-300x220.webp 300w, https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/periflux_6000_segmental_pressure_start-1-768x563.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n<div class=\"gn-spacer-block pb-32\">\n    <\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\"><div class=\"block-img relative   \" >\n                                        <img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/www.perimed-instruments.com\/us\/wp-content\/uploads\/sites\/3\/2024\/11\/foot-map_perimed.webp\" alt=\"\"\n                    width=\"722\" height=\"589\" class=\" has-round-corners\">\n                                <\/div>\n            <\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading has-h-2-font-size\" id=\"h-pericam-psi-for-pad\">PeriCam PSI for PAD<\/h3>\n\n\n\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-5f1e7b9a wp-block-group-is-layout-constrained\">\n<p class=\"has-p-regular-font-size\">PeriCam PSI provides a fast and accurate way to assess microcirculation in tissue by using laser speckle contrast imaging (LSCI). LSCI is a valuable tool for PAD assessment as the disease often involves impaired microcirculation. The technology provides a noninvasive way to assess blood flow in small vessels, helping to visualize areas of poor blood supply, which is crucial for identifying regions at risk of ulceration, delayed wound healing, or infection.<\/p>\n\n\n<div class=\"gn-spacer-block pb-10\">\n    <\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/us\/products\/pericam-imaging-systems\/pericam-psi\">Learn more about PeriCam PSI<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n        <\/div>\n    <\/section>\n\n\n<section class=\"relative w-full side-margins radius-8 form-bg mx-auto pt-20 2xl:pt-20 pb-20 none\" id=\"contact-form\">\n                        \n\n        <div class=\"section__content  max-w-screen-xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-white-color has-text-color has-link-color has-subheader-font-size wp-elements-d460a9b4f2d432b35f4358244135c513\">Contact us<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-white-color has-text-color has-link-color wp-elements-d1148a0da7ad4e1a6b6bf19d03015b3c\" id=\"h-get-in-touch\">Get in touch<\/h2>\n\n\n\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-d379e479 wp-block-group-is-layout-constrained\">\n<p class=\"has-white-color has-text-color has-link-color has-p-big-font-size wp-elements-9e1598fb4b834e66ce3f90447f23a58f\">Whether you\u2019re in a clinical or research setting, Perimed is here to support you with the tools and expertise needed for effective PAD management. Contact us to learn more about how our solutions can support your PAD diagnostics and start changing outcomes.<\/p>\n<\/div>\n\n\n<div class=\"gn-spacer-block pb-10\">\n    <\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.perimed-instruments.com\/us\/contact\/distributors\/\">Or locate your nearest distributor<\/a><\/div>\n<\/div>\n\n\n<div class=\"gn-spacer-block pb-10\">\n    <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"forms-block \" >\n            <div class=\"hs-form-frame\" data-region=\"na1\" data-form-id=\"e8e7b983-6449-44dc-a412-93c18c060218\" data-portal-id=\"19961763\"><\/div>\n    <\/div>\n<\/div>\n<\/div>\n\n\n        <\/div>\n    <\/section>\n\n\n<section class=\"relative w-full references mx-auto pt-12 2xl:pt-12 pb-12 2xl: none\" id=\"references\">\n                        \n\n        <div class=\"section__content  max-w-screen-xl px-4 mx-auto sec_no_tabs\" >\n            \n\n<p class=\"has-p-big-font-size\"><strong>References<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"has-p-tiny-font-size\">Eid, M. A., Mehta, K., Barnes, J. A., Wanken, Z., Columbo, J. A., Stone, D. H., Goodney, P., &amp; Mayo Smith, M. (2023). The global burden of peripheral artery disease.&nbsp;<em>Journal of vascular surgery<\/em>,&nbsp;<em>77<\/em>(4), 1119\u20131126.e1. <a href=\"https:\/\/doi.org\/10.1016\/j.jvs.2022.12.015\">https:\/\/doi.org\/10.1016\/j.jvs.2022.12.015<\/a><\/li>\n\n\n\n<li class=\"has-p-tiny-font-size\">Fuchs, D., Dupon, P. P., Schaap, L. A., &amp; Draijer, R. (2017). The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis.&nbsp;<em>Cardiovascular diabetology<\/em>,&nbsp;<em>16<\/em>(1), 11. <a href=\"https:\/\/doi.org\/10.1186\/s12933-016-0487-1\">https:\/\/doi.org\/10.1186\/s12933-016-0487-1<\/a><\/li>\n\n\n\n<li class=\"has-p-tiny-font-size\">Settembre, N., Kagayama, T., Kauhanen, P., Vikatmaa, P., Inoue, Y., &amp; Venermo, M. (2018). The Influence of Heating on Toe pressure in Patients with Peripheral Arterial Disease.&nbsp;<em>Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society<\/em>,&nbsp;<em>107<\/em>(1), 62\u201367. <a href=\"https:\/\/doi.org\/10.1177\/1457496917705994\">https:\/\/doi.org\/10.1177\/1457496917705994<\/a><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-p-big-font-size\"><strong><strong>LASCA and LSCI<\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-p-tiny-font-size\">Laser speckle contrast imaging (LSCI) is the innovative technology behind PeriCam PSI, offering non-contact, high-resolution perfusion imaging. The technique was first described by <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23014683\/\">J.D. Briers and S. Webster in 1996<\/a> and referred to as laser speckle contrast analysis (LASCA). In later years, the term LSCI gained in popularity and is nowadays the more common term. However, LSCI and LASCA both refer to the same technique, providing precise and reliable perfusion data without the need for contrast agents.<\/p>\n\n\n        <\/div>\n    <\/section>\n","protected":false},"excerpt":{"rendered":"<p>Peripheral artery disease (PAD) affects over 113 million people globally, contributing to pain, disability, and, in severe cases, amputation. Early detection and accurate monitoring are critical for managing this chronic condition.<\/p>\n","protected":false},"featured_media":2994,"parent":68,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":""},"application_cat":[25],"class_list":["post-1102","application","type-application","status-publish","has-post-thumbnail","hentry","application_cat-clinical"],"acf":{"page_layout":"fullwidth","page_header_style":"dark","page_hero_overlap_header":"no","page_custom_css":""},"_links":{"self":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/application\/1102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/application"}],"about":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/types\/application"}],"up":[{"embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/application\/68"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/media\/2994"}],"wp:attachment":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/media?parent=1102"}],"wp:term":[{"taxonomy":"application_cat","embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/application_cat?post=1102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}