{"id":813,"date":"2024-12-19T10:29:36","date_gmt":"2024-12-19T10:29:36","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=application&p=813"},"modified":"2025-01-16T11:48:20","modified_gmt":"2025-01-16T11:48:20","slug":"subcutaneous-tumor-model","status":"publish","type":"application","link":"https:\/\/www.perimed-instruments.com\/us\/applications\/preclinical-research\/subcutaneous-tumor-model\/","title":{"rendered":"Subcutaneous tumor model"},"content":{"rendered":"
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Home<\/a><\/span> \/ Applications<\/a><\/span> \/ Preclinical research<\/a><\/span> \/ Subcutaneous tumor model<\/span><\/span><\/div>\n\n\n

Subcutaneous tumor model<\/h1>\n\n\n\n

The subcutaneous tumor model is a popular assessment system for in vivo evaluation of cancer medicine candidates. This model often uses immunodeficient animal strains, where cultured cancer cells are implanted subcutaneously, taking about two weeks to produce a solid tumor.<\/p>\n\n\n

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Learn more<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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The growth and metastasis of cancer tumors rely on the development of blood vessels and an effective microcirculation. Without angiogenesis, a small focus of tumor cells cannot grow at a secondary site. As such, angiogenesis plays a central role in tumor growth, progression, invasion, and metastasis. Inhibiting angiogenesis provides a potential strategy for some treatments. <\/p>\n\n\n\n

Because it can measure and visualize blood perfusion in and around subcutaneous tumors over time, PeriCam PSI can help researchers monitor tumor progression and validate the efficacy of anti-angiogenic therapies for cancer treatment.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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Overcoming data collection challenges<\/h3>\n\n\n\n

Tumor tissue is dynamic, undergoing rapid changes in blood flow, hypoxia, and metabolic activity. Capturing these changes requires real-time, high-resolution data acquisition. PeriCam PSI addresses this challenge by supporting continuous, noninvasive monitoring.<\/p>\n\n\n\n

PeriCam PSI measures blood perfusion in a noninvasive, non-contact, and non-destructive way. This design approach supports longitudinal monitoring of angiogenesis without disruption to the tissue. <\/p>\n\n\n\n

While measurement tools cannot eliminate data variability caused by biological differences in test subjects and experimental conditions, they can help ensure that additional variability is not introduced into the results. PeriCam PSI is designed to deliver robust measurements \u2014 objective, repeatable, precise, and accurate \u2014 helping to minimize additional variability and enable cross-study comparisons.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI in practice<\/h3>\n\n\n\n
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These perfusion images generated by PeriCam PSI show a mouse ear with a subcutaneous tumor on day-14. <\/em>The images show how blood perfusion in the tumor increases in response to a heat challenge.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI HR<\/h3>\n\n\n
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PeriCam PSI leverages laser speckle contrast imaging (LSCI) to assess blood perfusion in tissue at the microcirculation level with detail and precision. PeriCam PSI HR (high resolution) works from a fixed distance and is specifically equipped to measure small animals such as rats and mice.<\/p>\n\n\n

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