{"id":828,"date":"2024-12-19T11:07:57","date_gmt":"2024-12-19T11:07:57","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=application&p=828"},"modified":"2025-01-15T13:27:57","modified_gmt":"2025-01-15T13:27:57","slug":"cerebral-blood-flow-monitoring","status":"publish","type":"application","link":"https:\/\/www.perimed-instruments.com\/us\/applications\/preclinical-research\/cerebral-blood-flow-monitoring\/","title":{"rendered":"Cerebral blood flow monitoring"},"content":{"rendered":"
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Home<\/a><\/span> \/ Applications<\/a><\/span> \/ Preclinical research<\/a><\/span> \/ Cerebral blood flow monitoring<\/span><\/span><\/div>\n\n\n

Cerebral blood flow monitoring<\/h1>\n\n\n\n

Cerebral blood flow monitoring leverages blood perfusion to understand and assess brain function. It is a popular biomarker among neuroscientists as it is indicative of many neurological conditions \u2014 such as stroke, traumatic brain injury (TBI), and Alzheimer\u2019s disease. With proper measurement tools, cerebral blood flow monitoring is suitable for assessing disease progression, the impact of therapeutic interventions, and the brain’s ability to recover.<\/p>\n\n\n

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Learn more<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Overcoming data collection challenges<\/h2>\n\n\n\n

Small or subtle variations in blood flow, especially in microcirculatory networks, are often critical for studying conditions like stroke, traumatic brain injury, and neurodegenerative diseases. These minute changes can be hard to measure without advanced tools. Leveraging laser speckle contrast imaging (LSCI), PeriCam PSI aims to overcome this challenge by delivering high-resolution images up to 10 \u03bcm\/pixel, providing researchers with an effective means to capture minute variations in blood flow.<\/p>\n\n\n\n

Continuous real-time data is a prerequisite for tracking dynamic processes like neurovascular coupling or the sudden influx of blood flow following ischemia that occurs in stroke, heart attack, and revascularization surgery. PeriCam PSI records these processes at a frequency of up to 100 images per second, capturing events at the required level of detail \u2014 spatially and temporally.<\/p>\n\n\n\n

Physiological factors like breathing, movement, or pulsation and external factors, such as vibration or ambient light fluctuation, can introduce artifacts into the data if they are not accounted for. PeriCam PSI is delivered on a high-quality arm that helps to prevent movement artifacts and automated background compensation ensures robust measurements under varying lighting conditions.<\/p>\n\n\n\n

Traditional imaging techniques often require contact with the tissue or contrast agents, which can disrupt natural physiology and compromise data integrity. PeriCam PSI helps address this challenge by providing clear insights into blood flow dynamics without physically affecting the tissue.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI in practice<\/h3>\n\n\n\n
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PeriCam PSI\u2019s high spatial resolution enables researchers to visualize an entire mouse brain, making it possible to characterize and precisely locate ischemic injury.<\/p>\n\n\n\n

Mouse brain. PeriCam PSI HR Courtesy Dr Offenhauser, Charit\u00e9, Berlin, Germany.<\/em><\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI HR<\/h3>\n\n\n
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PeriCam PSI leverages laser speckle contrast imaging (LSCI) to assess blood perfusion in tissue at the microcirculation level with detail and precision. PeriCam PSI HR (high resolution) works from a fixed distance and is specifically equipped to measure small animals such as rats and mice.<\/p>\n\n\n

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