{"id":842,"date":"2024-12-19T12:53:47","date_gmt":"2024-12-19T12:53:47","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=application&p=842"},"modified":"2025-01-15T13:29:18","modified_gmt":"2025-01-15T13:29:18","slug":"cutaneous-wound-healing","status":"publish","type":"application","link":"https:\/\/www.perimed-instruments.com\/us\/applications\/preclinical-research\/cutaneous-wound-healing\/","title":{"rendered":"Cutaneous wound healing"},"content":{"rendered":"
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Home<\/a><\/span> \/ Applications<\/a><\/span> \/ Preclinical research<\/a><\/span> \/ Cutaneous wound healing<\/span><\/span><\/div>\n\n\n

Cutaneous wound healing<\/h1>\n\n\n\n

To support the metabolic needs of tissue repair during wound healing, the formation of angiogenic capillaries and their organization into microvascular networks is essential. Diseases like diabetes disrupt this process, leading to wound-healing impairment. Owing to the global prevalence of this issue, the development of materials and therapeutics to promote wound healing is a major area of research.<\/p>\n\n\n

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Data collection challenges<\/h2>\n\n\n\n

Researchers often use the skin as a model for testing new treatments, such as topical drugs, dressings, biomaterials, <\/strong>and tissue-engineering techniques<\/strong>. Cutaneous wound healing can be used to evaluate how interventions influence the healing process and their potential to enhance wound closure or reduce scar formation.<\/p>\n\n\n\n

Following wound creation, subjects are measured at various intervals during the two-week healing period. Typically, researchers look for reductions in wound size and mature vasculature formation using CD31 and \u03b1-SMA immunohistochemistry. However, this approach involves euthanizing the animals at each measurement.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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Overcoming challenges with PeriCam PSI<\/h3>\n\n\n\n

PeriCam PSI can measure blood perfusion in wounds over the entire two-week healing period on the same animal, reducing the number of subjects needed and supporting robust findings. The data can be used to evaluate pro-angiogenic effects of therapeutic agents or natural recovery in healthy compared with diseased (diabetic) and wild-type contra knockout animals [1] [2] [3] [4]<\/a><\/sup>.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI HR<\/h3>\n\n\n
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PeriCam PSI leverages laser speckle contrast imaging (LSCI) to assess blood perfusion in tissue at the microcirculation level with detail and precision. PeriCam PSI HR (high resolution) works from a fixed distance and is specifically equipped to measure small animals such as rats and mice.<\/p>\n\n\n

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