{"id":858,"date":"2024-12-19T13:57:16","date_gmt":"2024-12-19T13:57:16","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=application&p=858"},"modified":"2025-01-17T08:22:58","modified_gmt":"2025-01-17T08:22:58","slug":"middle-cerebral-artery-occlusion-mcao","status":"publish","type":"application","link":"https:\/\/www.perimed-instruments.com\/us\/applications\/preclinical-research\/middle-cerebral-artery-occlusion-mcao\/","title":{"rendered":"Middle cerebral artery occlusion (MCAO)"},"content":{"rendered":"
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Home<\/a><\/span> \/ Applications<\/a><\/span> \/ Preclinical research<\/a><\/span> \/ Middle cerebral artery occlusion (MCAO)<\/span><\/span><\/div>\n\n\n

Middle cerebral artery occlusion<\/h1>\n\n\n\n

Middle cerebral artery occlusion (MCAO) is a widely used preclinical model for studying ischemic stroke. By replicating the effects of reduced blood flow to brain tissue, it induces localized ischemia and potential tissue damage.<\/p>\n\n\n\n

he MCAO model is instrumental in stroke research, understanding the physiological responses and testing the efficacy of new therapeutic approaches before they reach clinical trials. MCAO studies require precise data collection to capture the subtle, time-sensitive changes in blood flow and tissue perfusion that occur immediately after occlusion and during recovery.<\/p>\n\n\n

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Overcoming challenges<\/h2>\n\n\n\n

The degree of ischemia can vary widely depending on the method used to induce occlusion. Achieving reproducibility in the infarct’s size and location is also difficult, and small variations can alter the outcome. <\/p>\n\n\n\n

MCAO research relies on precise timing to capture changes during the critical phases of stroke onset, progression, and recovery.<\/p>\n\n\n\n

Monitoring microcirculatory changes in real-time without introducing artifacts is also complex. Traditional imaging techniques often require contact with the tissue or contrast agents, which can disrupt natural physiology and compromise data integrity. PeriCam PSI helps address this challenge by providing clear insights into blood flow dynamics without physically affecting the tissue.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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PeriCam PSI HR<\/h3>\n\n\n
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PeriCam PSI leverages laser speckle contrast imaging (LSCI) to assess blood perfusion in tissue at the microcirculation level with detail and precision. PeriCam PSI HR (high resolution) works from a fixed distance and is specifically equipped to measure small animals such as rats and mice.<\/p>\n\n\n

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