{"id":627,"date":"2024-12-17T10:34:57","date_gmt":"2024-12-17T10:34:57","guid":{"rendered":"http:\/\/www.perimed-instruments.com\/us\/?post_type=product&p=627"},"modified":"2025-01-15T12:17:42","modified_gmt":"2025-01-15T12:17:42","slug":"hr","status":"publish","type":"product","link":"https:\/\/www.perimed-instruments.com\/us\/products\/pericam-imaging-systems\/pericam-psi\/hr\/","title":{"rendered":"PeriCam PSI HR"},"content":{"rendered":"
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Home<\/a><\/span> \/ Products<\/a><\/span> \/ PeriCam imaging systems<\/a><\/span> \/ PeriCam PSI<\/a><\/span> \/ PeriCam PSI HR<\/span><\/span><\/div>\n\n\n

PeriCam PSI HR<\/h1>\n\n\n\n

Real-time perfusion imaging for research<\/h2>\n\n\n\n

Primarily designed for preclinical research, PeriCam PSI HR leverages laser speckle contrast imaging (LSCI) to measure blood perfusion in tissue at the microcirculation level with precision in real-time. The HR model is specifically equipped to measure small animals, such as rats and mice, in a non-destructive way \u2014 without contact, invasive probes, or tracer agents.<\/p>\n\n\n

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Data and images<\/h2>\n\n\n\n

PeriCam PSI HR converts blood perfusion in tissue into a continuous, real-time data stream of perfusion units. To simplify interpretation, the application software (PIMSoft) translates these measurements into clear, color-coded images and graphs.<\/p>\n\n\n\n

The color coding in these mouse brain perfusion images, for example, is set to the default, where blue and cyan indicate the lowest levels of perfusion, orange and red the highest, and green and yellow in between. <\/p>\n\n\n\n

In the experiment, researchers stimulate the whiskers on the right side of the mouse\u2019s head. The baseline and provocation images show the effect on blood perfusion on the left side of the brain. For easy comparison, PeriCam PSI HR provides difference images<\/strong> visualizing the change in perfusion between the baseline and provocation. Images are color-coded on a red-to-black-to-cyan scale: shades of red indicate increased perfusion from baseline to provocation, black represents no change, and shades of blue indicate decreased perfusion.<\/p>\n<\/div>\n<\/div>\n\n\n <\/div>\n <\/section>\n\n\n

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High resolution<\/h2>\n\n\n\n

Adapted for preclinical research where high resolution is desired to reveal details, PeriCam PSI HR works at a fixed distance of 13 cm and offers magnification optics of 10 \u00b5m\/pixel for up to 2.1 x 2.5 cm. With zoom functionality, measurement areas can be up to 20 x 24 cm.<\/p>\n\n\n\n

Zoom functionality<\/strong> unlocks the camera optics to expand the measurement flexibility of your instrument and broadens its field of application.<\/p>\n<\/div>\n\n\n\n

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Features<\/h2>\n\n\n
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Regions of interest (ROIs)<\/h2>\n\n\n
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To support targeted analysis, PeriCam PSI HR allows you to define regions of interest (ROIs). This feature facilitates observation of localized changes in perfusion in response to stimuli or interventions in specific areas, such as a part of the brain or tissue. ROIs can be customized in shape and size within PIMSoft, enabling precise and repeatable measurements for consistent results across experiments.<\/p>\n\n\n

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Time periods of interest (TOIs)<\/h3>\n\n\n
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In addition to regions of interest you can create time periods of interest \u2014 TOIs. This feature is valuable for observing how blood flow dynamics evolve in response to stimuli, treatments, or other interventions. By setting TOIs in PIMSoft, you can capture and analyze perfusion data at key moments, such as baseline and stroke, enabling you to identify and quantify immediate and delayed physiological effects.<\/p>\n<\/div>\n\n\n

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Perfusion overlay<\/h3>\n\n\n
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This feature enables perfusion images to be superimposed onto real images of the subject being studied, creating a precise visual alignment of physiological data with anatomical landmarks. Designed to help researchers see changes in localized blood flow relative to specific anatomical structures, pinpoint where perfusion changes occur, and analyze these in the context of targeted tissues or regions. <\/p>\n<\/div>\n\n\n

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Reports<\/h3>\n\n\n\n

The robust reporting functionality streamlines data analysis and documentation. With PIMSoft, you can automatically generate detailed reports that include key perfusion metrics, graphical data, and images of selected regions and times of interest. <\/p>\n\n\n\n

Reports can be customized to highlight specific data, such as perfusion changes over time, responses to interventions, or comparisons between baseline and post-stimulation measurements. Selected data can be exported as a PDF or spreadsheet, making it easy to share findings with colleagues, integrate data into broader studies, or include visual evidence in publications. This functionality is designed to save time while ensuring comprehensive, accurate records of research outcomes.<\/p>\n<\/div>\n\n\n\n

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Application areas<\/h2>\n\n\n\n
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PeriCam PSI HR is a versatile tool for preclinical research, providing high-resolution, real-time tissue perfusion that is critical to the investigation of physiological responses and disease mechanisms. Its noninvasive, laser-based imaging technology allows researchers to capture and quantify blood flow changes in small animals with precision, making it ideal for studies on vascular health, neurovascular function, wound healing, and drug efficacy.<\/p>\n<\/div>\n\n\n

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\n \"CAM\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n CAM assay\n <\/h3>\n\n
\n Measure the change in blood perfusion in the angiogenesis chicken embryo assay and detect differences in the efficacy of various pro-angiogenic compounds.\n <\/div>\n \n
\n \n \n Read more\n <\/span>\n \"Arrow\n about CAM assay<\/span>\n <\/span>\n <\/div>\n <\/div>\n <\/a>\n <\/div>\n \n
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\n \"Hindlimb\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n Hindlimb ischemia\n <\/h3>\n\n
\n An important model for studying PAD, PeriCam PSI delivers the data to confirm ischemia and validate the efficacy of a treatment strategy.\n <\/div>\n \n
\n \n \n Read more\n <\/span>\n \"Arrow\n about Hindlimb ischemia<\/span>\n <\/span>\n <\/div>\n <\/div>\n <\/a>\n <\/div>\n \n
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\n \"Cutaneous\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n Cutaneous wound healing\n <\/h3>\n\n
\n PeriCam PSI can measure blood perfusion in wounds over the entire two-week healing period on the same animal.\n <\/div>\n \n
\n \n \n Read more\n <\/span>\n \"Arrow\n about Cutaneous wound healing<\/span>\n <\/span>\n <\/div>\n <\/div>\n <\/a>\n <\/div>\n \n
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\n \"Neo\u00advascularization\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n Neo\u00advascularization and angiogenesis\n <\/h3>\n\n
\n Delivering the necessary data about new vessel formation through noninvasive and non-destructive methods.\n <\/div>\n \n
\n \n \n Read more\n <\/span>\n \"Arrow\n about Neo\u00advascularization and angiogenesis<\/span>\n <\/span>\n <\/div>\n <\/div>\n <\/a>\n <\/div>\n \n
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\n \"Cerebral\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n Cerebral blood flow monitoring\n <\/h3>\n\n
\n PeriCam PSI can generate visualizations of tissue blood perfusion in real-time without influencing it through contact, use of contrast dyes, or tracer elements.\n <\/div>\n \n
\n \n \n Read more\n <\/span>\n \"Arrow\n about Cerebral blood flow monitoring<\/span>\n <\/span>\n <\/div>\n <\/div>\n <\/a>\n <\/div>\n \n
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application_cat Preclinical research<\/div>\n
\n Preclinical research<\/span>\n <\/div>\n \n

\n Subcutaneous tumor model\n <\/h3>\n\n
\n Because it can measure and visualize blood perfusion in subcutaneous tumors over time, PeriCam PSI can help researchers monitor tumor progression and validate the efficacy of anti-angiogenic therapies for cancer treatment.\n <\/div>\n \n
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Contact Sales<\/p>\n\n\n\n

Get in touch<\/h2>\n\n\n\n

If you would like to know more about PeriCam PSI HR and how it can help you in your preclinical research, send us your contact details so that we can put a local representation in touch with you.<\/h4>\n\n\n
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Or locate your nearest distributor<\/a><\/div>\n<\/div>\n\n\n
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LASCA and LSCI<\/strong><\/strong><\/p>\n\n\n\n

Laser speckle contrast imaging (LSCI) is the innovative technology behind PeriCam PSI, offering non-contact, high-resolution perfusion imaging. The technique was first described by J.D. Briers and S. Webster in 1996<\/a> and referred to as laser speckle contrast analysis (LASCA). In later years, the term LSCI gained in popularity and is nowadays the more common term. However, LSCI and LASCA both refer to the same technique, providing precise and reliable perfusion data without the need for contrast agents.<\/p>\n\n\n <\/div>\n <\/section>\n\n\n

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Primarily designed for preclinical research, PeriCam PSI HR leverages laser speckle contrast imaging (LSCI) to measure blood perfusion in tissue at the microcirculation level with precision in real-time.<\/p>\n","protected":false},"featured_media":1877,"parent":604,"menu_order":0,"template":"","meta":{"_acf_changed":true,"inline_featured_image":false,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":""},"product-type":[],"class_list":["post-627","product","type-product","status-publish","has-post-thumbnail","hentry"],"acf":{"page_layout":"fullwidth","page_header_style":"dark","page_hero_overlap_header":"no","page_custom_css":""},"_links":{"self":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/product\/627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/types\/product"}],"up":[{"embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/product\/604"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/media\/1877"}],"wp:attachment":[{"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/media?parent=627"}],"wp:term":[{"taxonomy":"product-type","embeddable":true,"href":"https:\/\/www.perimed-instruments.com\/us\/wp-json\/wp\/v2\/product-type?post=627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}