Probes

A probe for every need

The high-quality Perimed laser Doppler probes allow the study of microcirculation in almost any organ or tissue. All probes are designed for PeriFlux 6000, PeriFlux System 5000 and PeriFlux System 4000.

Please contact Perimed for probes compatible with older PeriFlux laser Doppler models.

We offer a wide selection of probes as well as different types of disposable microtips for long-term implantation. All probes use a silica fiber with a core diameter of 0.125 mm. The probes are reinforced with Kevlar® for increased strength. Probes are available with fiber separations from 0.15 to 1.2 mm (standard separation is 0.25 mm) and a cable length of 2.50 m (other lengths available). Probes and microtips can be sterilized or disinfected.

SKIN PROBES

PROBE 404-1 Suturable Angled Probe

Multi-purpose, low-profile probe with one returning fiber. Especially suited for Skin Perfusion Pressure (SPP). It can be fixed to skin using double-sided tape strips or sutured. It can also be used invasively. Also available with extra returning fiber for increased sensitivity, especially when used on dark tissue and buried flaps







PROBE 404-NI Non-Invasive Angled Probe

Multi-purpose, low profile probe with one returning fiber. It is intended for non-invasive laser Doppler measurements of blood perfusion on intact skin. Especially suited for SPP measurements. The probe can be attached to the skin using PF 105-3 Double-sided Tape Strip.

PROBE 407 Small Straight Probe

Multi-purpose probe for fitting into different small probe holders for different applications. The soft, flexible design of the fiber line reduces the influence of artefacts from moving subjects. PROBE 407 can be used on other tissues in certain applications. Probe holders: All PH 07-X Probe Holder

Skin Probes with Heating Capability

PROBE 457 Thermostatic Small-Angled Probe

A combined laser Doppler and thermostatic probe for simultaneous blood perfusion measurement and local heat provocation. Double-sided tapes are used for fixation. The probe is watertight and can be kept in water for several hours.

INVASIVE PROBES

PROBE 411 Needle Probe for Micromanipulator

For acute invasive measurements. The support is designed to fit into a micromanipulator or laboratory stand for exact positioning. The tip is thin (0.45 mm) for easy penetration of tissue such as animal brain.

Tissue: Invasively in most organs and tissues

PROBE 404-1 Suturable Angled Probe

Multi-purpose, low-profile probe with one returning fiber. Especially suited for skin perfusion pressure (SPP). It can be fixed to skin using double-sided tape strips or sutured. It can also be used invasively. Also available with extra returning fiber for increased sensitivity, especially when used on dark tissue and buried flaps.

PROBE 407 Small Straight Probe

Multi-purpose probe for fitting into different small probe holders for different applications. The soft, flexible design of the fiber line reduces the influence of artefacts from moving subjects. PROBE 407 can be used on other tissues in certain applications. Probe holders: All PH 07-X Probe Holder

PROBE 418-1 Master Probe*

Not for human use. For animal research only.

Can easily be connected to/disconnected from a microtip. Microtips are useful for invasive measurements, for example, in muscle, and can be inserted into tissue through a 22 G/0.6 I.D. cannula. For mouse skulls, the microtips should be glued to the surface. Please contact Perimed for “Instructions for Use”.

Microtips: MT B500-0L120, MT B500-0L240
Tissue: Invasive measurements in soft tissue or on mouse skull during MCA occlusion.

CONSUMABLES FOR PROBES

Probe Holders and fixation tape

Perimed offers a wide range of probe holders for various probes and purposes. Probes and probe holders are usually fixed to the skin using double-sided tape and will remain fixed to the skin only for a maximum of some hours.

Perimed double-sided tapes are medical grade. The materials used have been tested over many years and are assessed and documented according to ISO 10993-1 guidance and principles. The use of probes, probe holders and sensors has been shown not to have any adverse effects on skin.

PF 1001 Refill Motility Standard

Calibrating the laser Doppler probes with our Motility Standard (PF 1001) before use is absolutely essential. The Motility Standard consists of a colloidal suspension of polystyrene particles.

The Motility Standard should be replaced annually due to possibility of contamination during regular use.

Microtips

Implantable microtips (single-fiber probes of 120 mm or 240 mm in length) can either be sutured or glued in place using a medical-grade cyanoacrylate adhesive. This adhesive can usually be loosened with acetone or a proprietary adhesive remover. However, note that this type of adhesive may cause local tissue damage. Alternatively, the probe can be fitted into a micromanipulator which allows the probe and microtip to be positioned in contact with the tissue in a controlled manner.

Part number Product name
91-00124 MT B500-0L120 Straight Microtip (5 pcs)
91-00123 MT B500-0L240 Straight Microtip (5 pcs)
STROKE MODEL KIT

Stroke Model Monitor for Mice and Rats

The Stroke Model System is used for simple detection of whether a stroke has been successfully induced in mice and/or rats. Successful middle cerebral artery occlusion (MCAO) is confirmed by real-time monitoring of a ~70% decrease in regional cerebral blood flow.

Specialized kits for rats or mice

For the application on mice, we recommend Master Probe 418 into which a microtip is inserted. The microtip is attached directly to the skull using the glue + accelerator provided in Stroke Model Kit 418. Microtips are available in lengths 120 mm and 240 mm.

For rats, we recommend PROBE 407 which is attached to the skull with probe holder PH 07 using Stroke Model Kit 407.

* ”Please note that this device will be discontinued for human use in Europe May 25:th 2020 when the new European Medical Device Regulations becomes mandatory for Class 1 devices. After this date it will not be CE marked in Europe and cannot be sold for human use. Note, this is only for Europe and not for the rest of the world. Also note that devices purchased before May 25:th 2020 still can be used for human use on the European market.”

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Disclaimer: It is possible that the products on the Perimed website may not be cleared for sale in all markets.