Iontophoresis is a technique to transport charged molecules or drugs across a tissue barrier. Combined with the laser Doppler or laser speckle techniques, iontophoresis is a valuable tool for diagnosis and studying endothelial dysfunction.
The perfusion can be measured by laser Doppler using a specialized delivery electrode with integrated laser Doppler probe or a laser speckle contrast imager, using a transparent delivery electrode for use with the imager.
Iontophoresis is a technique that can be used to transport drugs in ionic form across intact skin. Depending on the chosen drug, this may or may not affect the local blood perfusion. The technique is based on the principle that an electric potential will cause ions in a solution to migrate according to their electrical charges.