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Real-time microcirculation imagingPeriCam PSI System

  • Up to 100 images per second
  • Measurement area - up to 24 x 24 cm
  • Intuitive and user friendly software


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PeriCam PSI System - Blood Perfusion Imager

The PeriCam PSI System is a blood perfusion imager based on the Laser Speckle Contrast Analysis (LASCA) technology. It is a method that visualizes tissue blood perfusion in real-time. LASCA provides new means to study the microcirculation in ways that were not possible in the past. The PeriCam PSI System combines dynamic response and high spatial resolution in one instrument, providing both real-time graphs and video recordings of the area of interest. To further enhance its usability, dedicated application software, PIMSoft, has been developed.

The PeriCam PSI System is available in two versions; normal resolution PeriCam PSI NR, and high resolution PeriCam PSI HR.

Features

Easy to get started – flexible to use

The PeriCam PSI is easy to get started and to operate it is flexible to adjust and position at any measurement angle. A color camera for documentation, an indicator laser and automated working distance calculation increases the simplicity.

Pre-defined Regions Of Interest (ROIs) allows for real-time analysis of data while recording, with instant update of data, graphs and images.

Automated background compensation once per second allows for stable and accurate measurements at varying lighting conditions.

System Design Principle

The PeriCam PSI System uses a 785 nm invisible laser for blood perfusion measurements. The beam is spread over the measurement area by a diffuser creating a speckle pattern. The size of the illuminated area depends on the distance between the laser aperture in the head and the measurement object.

The speckle pattern in the illuminated area is monitored using a 1388 x 1038 pixel CCD camera that can take images at a speed of up to 100 frames per second. Blood perfusion is calculated by analyzing the variations in the speckle pattern.

To facilitate the positioning of the imager relative to the subject a visible near infra-red (NIR) laser (650 nm) is used to indicate the maximum measurement area at a certain measurement distance. To avoid interference with measurements the indicator laser is switched off during recording. Both the measurement laser and the indicator laser are safe to use without eye protection.

A separate color camera is used for documentation. The capture rate can be set at different speeds during a recording, up to 1 frame per second. The color photos provide an extra help when analyzing the perfusion data, assuring that the object has not moved during the recording and for understanding the obtained blood perfusion images.

PimSoft: all-in-one data analysis

Blood perfusion is presented both as color-coded images and in graphical form, enhancing the possibilities for understanding and analyzing the microcirculatory data. Specific regions of interest (ROIs) can be defined before, during or after a completed recording. In addition, ROIs may be implemented during sections of a run. Time periods Of Interest (TOIs) allow for evaluation of blood perfusion during specific time periods. Event markers with comments may be added at any time.

Automatically calculated values include mean, percentage change, number of measurement points, standard deviation and more. Selected data is conveniently exported as .pdf reports or in .xml format for further processing.

Instrument versions

PeriCam PSI Normal Resolution

PeriCam PSI NR is used in the clinic and in research applications where it is desired to image blood perfusion in larger areas. A flexible working distance from 10 to 40 cm allows measurement areas up to 24 x 24 cm. Tissue blood perfusion is visualized in real time with a resolution of 100 µm/pixel.

PeriCam PSI NR is a valuable and objective tool for assessment of the skin microvascular function for clinical diagnosis. One of the common applications in the clinic is Burn depth estimation. The imager can be mounted on a cart with a flexible arm that makes it easy to position and reach a patient lying on a bed.

Common human research applications include the study of Endothelial Function by combining imaging with iontophoresis or PORH.

PeriCam PSI High Resolution

PeriCam PSI HR is used in animal research applications where high resolution in small measurement areas is desired. High magnification optics visualizes details of 20 µm/pixel in areas up to 20 x 27 mm.

The imager is mounted on a microscope stand for precise positional adjustment at a fixed working distance of 10 cm.

PeriCam PSI HR is an excellent tool for imaging of the cortical blood perfusion in mice and rats, e.g. stroke models. Other common applications are angiogenesis models as the ischemic hindlimb model. Read more about different applications by following the link below.

Applications
Stroke model imaging (MCAO) Stroke model imaging (MCAO)
Mouse brain
Mouse brain
Ischemic hind limb NR Ischemic hind limb NR
Ischemic hind limb HR Ischemic hind limb HR
Mouse intestine Mouse intestine
Iontophoresis Iontophoresis
PORH
Burn wound assessment Burn wound assessment
Burn wound assessment Burn wound assessment
Burn wound healing Burn wound healing
Flap survival Flap survival
Ischemic toe assessment Ischemic toe assessment

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Improving quality of life since 1981

Perimed AB, established in 1981, provides instruments, software and expertise to enable assessment of the microcirculation. We utilize laser Doppler, laser speckle (LASCA) and transcutaneous oxygen (tcpO2 or TCOM), to accurately monitor and quantify blood perfusion and tissue oxygenation in real-time. Our modular PeriFlux System 5000 and PeriFlux 6000, the latest generation of our PeriFlux System, are excellent choices for diagnosing Peripheral Arterial Disease (PAD) and Critical Limb Ischemia (CLI) or for assessing wound healing potential in your vascular patients. Our blood perfusion imagers PeriScan PIM 3 System and PeriCam PSI System, allow you to investigate spatial distribution, for example during cortical spreading depression.